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使用全基因组测序对Clostridium perfringens引起肝的表征:一个病例报告和文献综述

Muqi Li¹, Yan Min², Kun Ye¹

¹Department of Laboratory Medicine, the First Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China.

Infection and drug resistance

|March 4, 2026

概括

克洛斯特里迪乌 (Clostridium perfringens) 在经过静脉外科手术后的患者中引起了肝. 全基因组测序揭示了毒素和抗菌素耐药性基因,有助于理解和管理这种感染.

科学领域:

传染性疾病传染性疾病
微生物学微生物学
基因组学就是基因组学.

背景情况:

肝是一种严重的感染,通常需要复杂的管理.
杆菌是已知的病原体,但其在肝中的作用较少被报道.

研究的目的:

为了确定持续的术后发烧和肝脏的致病原体.
描述已识别的病原体的基因组和毒性因素.
对Clostridium perfringens诱导的肝的临床数据进行审查和背景化.

主要方法:

超声波和CT扫描用于诊断.
血液和液体培养物用于病原体隔离.
用于识别的矩阵辅助激光脱/离子化飞行时间质谱 (MALDI-TOF-MS).
全基因组测序 (WGS) 用于基因组分析.
对类似案件的文献综述.

主要成果:

菌被确定为肝脏的原因.
基因组分析揭示了克隆起源和关键毒素基因 (plc,pfoA,colA,cloSI) 和侵入性因素的存在.
鉴定出了抗微生物耐药性基因 (mprF,tetB(P,cplR).
文献综述强调了诸如年龄,男性性别,肝胆道疾病和糖尿病等倾向因素.

结论:

杆菌可以导致肝,特别是在患有易感因素的患者中.
基因组特征提供了对毒性和潜在耐药性的洞察力.
这项研究支持加强对C. perfringens肝的诊断,风险评估和治疗策略.

关键词:

克洛斯特里 (Clostridium perfringensens) 是一种有毒的植物.案例报告案例报告肝脏的情况肝脏毒性因素是毒性的因素.进行全基因组测序.

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