肺移植后与性结肠炎复发相关的支气管病变:一个病例报告
Fawwaaz Nassurally1, Erwan Pencreach2, Sandrine Hirschi1
1Strasbourg Lung Transplant Program, Strasbourg University Hospital, Strasbourg, France.
ERJ open research
|March 4, 2026
概括
本案例研究详细介绍了肺移植后性结肠炎相关的支气管炎复发. 接受者起源的呼吸道炎症和新的支气管支架被证实,突出了免疫介导的并发症.
科学领域:
- 肺部医学 肺部医学
- 移植免疫学 移植免疫学
- 胃肠病学 胃肠病学
背景情况:
- 支气管切除症可能与炎症性肠道疾病有关,例如性结肠炎.
- 肺移植是末期肺病的治疗选择.
- 移植后的并发症可能涉及呼吸道炎症和疾病复发.
研究的目的:
- 在肺移植后报告一种罕见的性结肠炎相关的支气管炎复发病例.
- 为了调查肺移植接受者新发支气管和气道透的病因.
- 利用嵌合体分析和免疫谱系研究来了解潜在的机制.
主要方法:
- 案例报告的呈现方式.
- 化学反应分析以确定捐赠者-接受者的细胞来源.
- 免疫谱系测序以评估T细胞受体多样性和克隆性.
- 呼吸道活检的组织病理学检查.
主要成果:
- 患者经历了肺移植后的支气管切除症复发.
- 确定了新的支气管切除变化和炎症性气道透.
- 化学反应分析和免疫谱系研究证实了炎症细胞的受体起源和新的病理学.
- 观察到免疫介导的呼吸道损伤的证据.
结论:
- 性结肠炎相关的支气管炎在肺移植后可能复发.
- 接收者衍生的免疫反应可以导致呼吸道炎症和移植后的新支气管病变.
- 化学和免疫谱系分析是阐明肺移植后呼吸道并发症机制的宝贵工具.
更多相关视频
相关概念视频
Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Pneumothorax-II
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...


