制造金属β-乳糖酶的肠杆菌感染的管理:修改后的Delphi研究
Yehuda Carmeli1, Mark Price2, George L Daikos3
1The National Institute of Antibiotic Resistance and Infection Control, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
JAC-antimicrobial resistance
|March 4, 2026
概括
产生金属β-乳糖酶 (MBL) 的肠杆菌感染是全球面临的重大威胁. 专家建议针对MBL进行向治疗,优先考虑使用aztreonam-avibactam等药物进行单一治疗.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 产生金属β-乳糖酶 (MBL) 的肠杆菌感染是全球医疗保健面临的重大和日益增长的挑战.
- 这些感染与高发病率,死亡率,长时间住院和增加医疗保健成本有关.
研究的目的:
- 达成国际专家共识,以最佳管理由MBL产生的肠杆菌引起的严重感染.
- 为了解决目前这些难以治疗的感染的有限治疗选择.
主要方法:
- 采用了经过修改的Delphi过程,调查了10名在抗菌素耐药性细菌感染管理方面的专家医生.
- 共识陈述是基于调查答复而制定的,并通过虚拟小组会议来改进.
主要成果:
- 专家一致认为,产生MBL的肠杆菌是抗菌素耐药性和感染的主要来源.
- 当可用时,阿兹特雷诺姆-阿维巴克坦是首选的第一线治疗方法,在体外表现出对新德里MBL产生肠道细菌的高活性.
- 当偏好的药物无法使用时,需要有限的治疗选择,主要是同时使用抗微生物药物.
结论:
- 对于产生MBL的肠杆菌感染有必要进行有针对性的治疗,达成共识.
- 当有效药物可用时,单疗法是首选的治疗策略.
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