相关实验视频
Updated: Jul 25, 2026
14:43
Synthesis of Keratin-based Nanofiber for Biomedical Engineering
Published on: February 7, 2016
14.6K
羽毛创新:将回收式质转化为生物活性微/纳米颗粒,用于基于生物活性质的交付平台
Lidija Fras Zemljič1, Lidija Tušek2, Anja Mešl3
1University of Maribor, Faculty of Mechanical Engineering, Institute of Engineering Materials and Design Smetanova 17 SI-2000 Maribor Slovenia lidija.fras@um.si.
RSC advances
|March 4, 2026
概括
废弃的羽被转化为质纳米颗粒用于药物输送. 这些素-TPP颗粒有效地封装了阿莫西西林,显示出受控释放和对大肠杆菌和金黄色杆菌的增强抗菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 可持续化学 可持续化学
背景情况:
- 废物生物质利用对于可持续的资源管理至关重要.
- 的羽毛废物是丰富的氨酸来源,一种天然的聚合物.
- 基基材料为新型生物复合材料和药物输送系统提供了潜力.
研究的目的:
- 探索亚临界提取的蛋白在形成静电稳定粒子方面的潜力.
- 为了评估这些基氨酸基质颗粒作为一个多功能药物输送平台.
- 使用酸盐,酸盐和TPP合成和表征酸盐-多电解质复合物.
主要方法:
- 使用在180°C的亚临界水 (SubCW) 来从羽中提取蛋白.
- 通过将质素与天然多电解质 (酸盐,酸盐) 和TPP复合合成颗粒.
- 使用动态光散射 (DLS) 和减弱总反射率里埃转换红外 (ATR-FTIR) 光谱学进行表征.
- 用阿莫西西林进行药物输送评估,包括封装效率和通过UV/VIS光谱学释放动力学.
- 对大肠杆菌和黄金杆菌的抗菌活性评估.
主要成果:
- 亚临界水提取产生了适合颗粒形成的质.
- 氨酸-TPP复合物形成了体颗粒,而氨酸-酸盐和氨酸-酸盐形成了微粒.
- ATR-FTIR证实了电静态相互作用驱动复合体形成.
- 氨酸-TPP颗粒显示69%的阿莫西西林封装效率和96%的释放超过6小时.
- 与纯氨基素相比,素-TPP输送平台表现出增强的抗微生物抑制.
结论:
- 亚临界提取的可以形成有效的药物递送颗粒,特别是-TPP复合体.
- 这些基于质素的颗粒提供了一个可持续的平台,有可能同时具有抗氧化和抗菌性质.
- 开发的氨酸-TPP-阿莫西西林系统显示了增强药物输送应用的前景.
相关概念视频
01:24iChip
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
01:27Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
01:28Microbial Bioremediation of Plastics
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...