炎症性肠病患者中的缺乏:系统性审查和元分析
Rahman Hameed Mohammed Abdul1, Nafisa Reyaz2, Abebe Yigzaw3
1Gastroenterology and Hepatology, Royal Derby Hospital, Derby, GBR.
Cureus
|March 4, 2026
概括
缺乏症在炎症性肠病 (IBD) 中很常见,影响到35%的患者. 克朗氏病患者的患病率更高,这凸显了IBD管理中需要进行营养查和评估的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 临床研究 临床研究
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,与各种营养缺乏有关.
- 在免疫功能和肠道健康中起着至关重要的作用,使其在IBD管理中的地位变得重要.
研究的目的:
- 系统地审查和元分析诊断为炎症性肠病 (IBD) 的患者中缺乏的流行情况.
- 为了比较IBD亚型之间的缺乏率,特别是克罗恩病和性结肠炎.
主要方法:
- 在主要的生物医学数据库 (PubMed/MEDLINE,Embase,Scopus,Web of Science,Cochrane Library) 进行了全面的文献搜索,截至2025年11月.
- 经过严格的选择和质量评估,包括了7项涉及2,403名IBD患者的研究.
- 随机效应模型被用于元分析,分组分析按IBD亚型分层.
主要成果:
- 在IBD患者中,缺乏的综合流行率为35% (95% CI:19-52%),观察到显著的异质性 (I2 = 98.5%).
- 与性结肠炎患者 (33%,95% CI: 18-51%) 相比,缺乏症在克罗恩病患者中更为普遍 (40%,95% CI: 21-59%).
结论:
- 缺乏症在IBD患者群体中是一个重要的营养挑战.
- 常规的营养查和评估建议IBD患者,特别是克罗恩病患者,以指导向补充剂,并可能改善结果.
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