精确选择患者进行消化和节奏:一项多中心研究,将无心脏起器与标准心脏起器比较,针对心房动 (LEAD-AP) 进行消化和节奏的患者
Ingrid Overeinder1, Luigi Pannone1, Domenico Laviola1
1Heart Rhythm Management Centre, Universitair Ziekenhuis Brussel, Heart Rhythm Research Brussels, Postgraduate Program in Cardiac Electrophysiology and Pacing, Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium.
Frontiers in cardiovascular medicine
|March 4, 2026
概括
无心脏起器的安全性和有效性与传统的输血器件相提并论,适用于患有永久性心房 (AF) 的患者,正在接受切除和节奏. 这种方法也大大减少了住院时间.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 电子生理学 电子生理学
背景情况:
- 通过心室节律 (心室节律) 进行心室节点 (AVN) 切除.
- ablate-and-pace") 在永久性心房动 (AF) 中有效控制心率.
- 传统的透静脉起器携带与和口袋相关的并发症的风险.
- 无心脏起器是一种潜在的替代品,但对比数据有限.
研究的目的:
- 为了比较无和透静脉单腔心脏起器在接受AVN切除治疗永久性AF的患者中的临床结果.
- 评估无心脏起器在美国的安全性和有效性.
- 设置"减速和节奏"设置.
主要方法:
- 在168名接受治疗的患者中进行了回顾性多中心研究 (LEAD-AP).
- 在2017年至2024年期间"废弃和步伐".
- 患者接受了无心脏起器 (n=56) 或输静脉VVI心脏起器 (n=112).
- 主要疗效终点:死亡率,AF相关住院病例和设备相关事件的组合. 主要安全终点:急性并发症在30天内.
主要成果:
- 无组的单步比率更高,单步比率更高.
- 降低和节奏" (96.4%与10.9%,p<0.001) 和较短的住院时间 (1.1与5.7天,p=0.008).
- 在24个月后,无和输血组之间对初级疗效终点的无事件生存没有显著差异 (82.1%与80.4%,p=0.29).
结论:
- 无心脏起器的安全性和有效性与静脉输入系统的安全性和有效性相美.
- 消化和节奏"的患者.
- 无系统有助于简化单一步骤的方法,从而缩短住院时间.
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