2型糖尿病患者便秘的临床特征和相关因素
Yan Fang1,2, Jiahao Chen1, Chendong Ni1
1Department of Endocrinology, the Second Affiliated Hospital, Soochow University, Suzhou, China.
Frontiers in endocrinology
|March 4, 2026
概括
较低的时间范围 (TIR) 和较高的葡萄糖变性 (CV) 与2型糖尿病 (T2DM) 患者的便秘有关. 持续血糖监测 (CGM) 指标可以预测便秘风险.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 2型糖尿病 (T2DM) 经常与胃肠道并发症有关,包括便秘.
- 在T2DM患者中,血糖控制指标和便秘之间的关系需要进一步阐明.
研究的目的:
- 调查T2DM患者便秘的临床特征.
- 探索血糖控制参数之间的相关性,特别是葡萄糖的时间范围 (TIR) 和变化系数 (CV),以及T2DM中便秘的存在.
主要方法:
- 一项探索性,横截面研究涉及120名T2DM患者,分为便秘和非便秘组.
- 对各种血液指标 (HbA1c,脂质等) 的评估. 使用验证的问卷,评估便秘症状,胃衰竭和生活质量.
- 持续14天的葡萄糖监测 (CGM) 用于计算TIR和CV,随后使用接收器运行特征曲线 (ROC) 进行分析,以评估它们对便秘风险的影响.
主要成果:
- 便秘患者表现出更严重的症状和更差的生活质量得分.
- 便秘组的疾病持续时间更长,糖尿病并发症的发病率更高,如自主神经病变和病.
- 在便秘组中观察到显著降低的禁食C- (FCP) 和更高的HbA1c,总胆固醇 (TC) 和LDL-C.
- 在T2DM患者中,TIR和CV都与便秘有显著的相关性.
结论:
- 较低的TIR和较高的CV与T2DM中便秘有关.
- 像TIR和CV这样的CGM衍生的指标可以作为预测T2DM患者便秘风险的有价值指标.
- 需要进一步的前性研究来证实这些发现,并探索针对血糖变化的治疗干预措施,以预防便秘.
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