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Updated: Jun 5, 2026

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Arterial Pouch Microsurgical Bifurcation Aneurysm Model in the Rabbit
Published on: May 14, 2020
诊断后焦虑和抑郁增加破裂风险和死亡率在未破裂的内动脉瘤.
Muhammed Amir Essibayi1, Ahmed Y Azzam2, Hamza Adel Salim3,4
1Department of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (M.A.E., A.K., D.K., N.H., D.J.A.).
Stroke
|March 4, 2026
概括
患有未破裂的内动脉瘤的患者的焦虑和抑郁症诊断与更高的死亡率和破裂风险有关. 综合精神病学评估可以改善患者的管理和结果.
科学领域:
- 神经学和精神病学 精神病学
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 诊断后焦虑和抑郁症对未破裂内动脉瘤 (UIA) 患者的结果的影响尚不清楚.
- 这项研究调查了焦虑/抑郁和治疗模式/结果在一个大UIA患者队列之间的关联.
研究的目的:
- 评估诊断后焦虑和抑郁症之间的关联以及未破裂的内动脉瘤患者的结果.
- 评估对死亡率,动脉瘤破裂和治疗模式的影响.
主要方法:
- 使用 TriNetX 全球协作网络 (2015-2025) 的回顾性队列研究,涉及超过1.3亿名患者.
- 确定了127,361名患有UIA的成年人,采用了127天的里程碑式分析来缓解不朽时间偏差.
- 1:1倾向得分匹配创建了6800名焦虑/抑郁症患者和6800名对照人群的队列,用于使用Cox比例危险模型进行结果分析.
主要成果:
- 焦虑/抑郁症与明显更高的全因死亡率 (HR 1.28) 和动脉瘤破裂 (HR 1.33) 相关.
- 与对照组 (95.5%) 相比,焦虑/抑郁队列的五年生存率较低 (93.7%).
- 观察到精神病药物坚持和死亡风险之间存在剂量反应关系.
结论:
- 诊断后焦虑和抑郁症与UIA患者的死亡率和破裂风险增加有关.
- 结果表明,在未破裂的内动脉瘤的管理中,应该考虑综合精神病学评估.
- 需要进一步的研究来确定因果关系和完善管理策略.
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