脑卒中史对认知功能,白质超强度和循环BDNF水平的影响
Farnaz Hashemi1, Saeed Malihi-Alzakerini1, Shima Shakiba2
1Department of Health Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Archives of Iranian medicine
|March 4, 2026
概括
脑卒中史影响认知功能和大脑健康. 患有中风病史的患者表现出较低的认知评分和脑衍生神经营养因子 (BDNF) 水平,白质强度增加 (WMHs).
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
背景情况:
- 脑卒中史显著影响患者的神经状态.
- 白质超强度 (WMHs) 在中风患者中很常见.
- 大脑衍生神经营养因子 (BDNF) 在神经元健康中起作用.
研究的目的:
- 为了研究中风史对认知功能的影响.
- 评估中风史和白质超强度 (WMHs) 之间的关系.
- 检查与中风史有关的循环大脑衍生神经营养因子 (BDNF) 水平.
主要方法:
- 分析了228名中风患者,根据中风史分类.
- 使用磁共振成像 (MRI) 来评估WMH负担.
- 蒙特利尔认知评估 (MoCA) 和BDNF水平被测量.
主要成果:
- 患有中风病史的患者的MoCA得分和血BDNF水平显著降低.
- 在中风组中观察到较高的白质强度负担.
- 调整分析对年龄,性别,教育和居住地进行控制.
结论:
- 一种多生物标志物方法 (MoCA,Fazekas得分,BDNF) 提供了对中风后神经状况的洞察.
- 早期检测和干预策略可能会改善患者的治疗结果.
- 这项研究强调了评估中风患者的认知功能,WMH和BDNF的重要性.
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