最近被诊断为心房的患者的节律控制:来自GLORIA-AF注册第三阶段的发现
Bernadette Corica1,2, Giulio Francesco Romiti1,3, Marco Proietti4,5
1Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart and Chest Hospital Liverpool UK.
Journal of the American Heart Association
|March 4, 2026
概括
在现实环境中治疗心房动 (AF) 的节律控制疗法有利于患者. 这种方法在三分之一的AF患者中使用,与更好的结果和增加口服抗凝剂的使用有关.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 公共卫生 公共卫生
背景情况:
- 建议早期节律控制,以改善心房动 (AF) 患者的治疗结果.
- 关于AF中节律控制有效性的现实数据有限.
- 这项研究评估了最近被诊断为AF患者的节律控制.
研究的目的:
- 为了评估节律控制策略的有效性,在一个现实世界队列的患者最近被诊断出心房动.
- 确定与节律控制的采用及其对主要心血管不良事件的影响相关的因素.
主要方法:
- 从GLORIA-AF注册第三阶段的21051名近期被诊断出AF的患者的分析.
- 节律控制被定义为抗节律失常药物治疗,AF切除或心脏转变.
- 多变量回归用于分析因素和结果,主要结果是全因死亡和主要不良心血管事件.
主要成果:
- 32.9%的患者接受了节律控制.
- 节律控制与更高的口服抗凝剂使用有关 (OR,1.36).
- 3年的随访表明节律控制与初级复合结果 (HR,0.88) 的风险较低有关.
结论:
- 节律控制在真实世界AF患者的三分之一中未得到充分利用.
- 节律控制与增加口服抗凝剂使用有关.
- 在AF患者中,节律控制与改善的临床结果有关.
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