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Updated: Mar 6, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
08:15

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System

Published on: April 11, 2025

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在内源性interleukin-1alpha中核定位序列的CRISPR修改后的炎症反应

Christopher Hoyle1,2,3, Rodrigo Díaz Pino3,4, Si Min Lai3,4

  • 1Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PT, UK.

Disease models & mechanisms
|March 4, 2026
PubMed
概括

我们创建了一个小鼠模型,破坏了Interleukin-1α (IL-1α) 的核定位. 这种突变增加了IL-1α蛋白,但在体内没有改变炎症反应,这表明核进口对其功能并不重要.

关键词:
细胞因子细胞因子炎症 炎症是一种炎症.流感是一次流感.互乐金-1αα是什么意思核部位定位 核部位定位

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