低强度的体外冲击波疗法在血管性勃起功能障碍中耐受PDE5抑制剂:一项前性研究,12个月和18个月的结果
Giuseppe Saitta1, Giuseppe Di Paola1, Simone Di Salvatore2
1Istituto Clinico Città Studi, Milan.
概括
低强度体外冲击波疗法 (Li-ESWT) 为血管性勃起功能障碍 (ED) 提供了一种安全有效的治疗方法,该疗法对PDE5抑制剂无反应. 对于ED患者来说,最大的好处是在12个月内看到的,在许多情况下持续改善.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 再生医学是一种再生医学.
- 男人的健康 男人的健康
背景情况:
- 低强度体外冲击波疗法 (Li-ESWT) 是一种针对血管性勃起功能障碍 (ED) 的新疗法.
- 对于那些对固酶类型-5抑制剂 (PDE5-Is) 无反应的患者来说,它特别重要.
研究的目的:
- 评估Li-ESWT在患有血管性ED的男性中的可行性和安全性.
- 通过未来的12个月和18个月的随访来评估Li-ESWT的临床有效性.
主要方法:
- 一项前性观察性研究包括188名患有血管性ED的男性,对PDE5-Is的反应不佳.
- 患者每周接受6次Li-ESWT治疗.
- 使用国际勃起功能指数 (IIEF) 和勃起硬度得分 (EHS) 来测量勃起功能.
主要成果:
- 在12个月后,IIEF-EF和EHS的显著改善被观察到,在65%的患者中持续存在益处.
- 年轻的年龄,更短的ED持续时间和中度的基线严重程度预测了对Li-ESWT的更好的反应.
- 虽然疗效在18个月后略有下降 (54%持续改善),但没有报告任何不良事件.
结论:
- -ESWT是对PDE5-Is耐药的血管性ED患者的安全有效的治疗选择.
- 通常在治疗12个月内获得最大的临床益处.
- 建议进行进一步的受控研究,以确定长期结果.
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