儿科过度活动膀的延长过程的穿皮神经刺激:一个6个月的前性单臂研究
Fangzheng Cheng1, Jian Wang2, Dongming Wang1
1Jian Wang Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
World journal of urology
|March 4, 2026
概括
将儿科过活性膀 (OAB) 的穿皮神经刺激 (TTNS) 延长到24周,改善了症状,并确定了许多迟反应者. 持续的TTNS可能有利于非响应者,这需要进一步研究.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 儿科泌尿外科 儿科泌尿外科
- 神经调节是一种神经调节.
背景情况:
- 儿科过度活性膀 (OAB) 显著影响生活质量.
- 穿皮神经刺激 (TTNS) 是对OAB的公认治疗方法.
- 对于儿科OAB的TTNS的最佳持续时间仍在调查中.
研究的目的:
- 评估在患有OAB的儿童中将TTNS治疗时间从12周延长到24周的额外临床益处.
- 为了识别和描述那些对TTNS治疗反应迟来的患者.
主要方法:
- 进行了一项前性单臂队列研究.
- 基于家庭的TTNS在基线,12周和24周进行了评估.
- 主要结局是OAB症状评分 (OABSS) 的变化,响应者以≥3分的最小临床重要差异 (MCID) 定义.
主要成果:
- 将TTNS延长到24周显示,响应率显著增加 (对照风险差异为0.175,p=0.000122).
- 超过一半 (51.9%) 的初始非响应者在12周成为响应者在24周.
- 平均OABSS在12周 (3.64±2.25) 和24周 (5.14±2.63) 均比基线有所改善.
结论:
- 将TTNS治疗延长到24周,在儿科OAB患者中提供了额外的症状改善.
- 很大一部分患者表现出对TTNS的晚期反应,而不会失去最初的收益.
- 超过12周的持续TTNS是早期不响应患者的潜在策略,需要通过随机对照试验进行验证.
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