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耳中的神经动态:听力状况对时间大脑活动可变性的差异性影响

Haoliang Du^1,2, Xiaoyun Qian^1,2, Xia Gao^1,2

¹Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, P. R. China.

Brain imaging and behavior

|March 4, 2026

概括

耳神经动态根据听力状况而异. 听力正常的耳声显示了感官区域的超变性,而听力受损的耳声与痛苦相关. 这两组都表现出较低的额头活动变异性.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
听觉神经科学听觉神经科学

背景情况:

耳,或幻影声音感知,有各种各样的原因,受听力能力的影响.
了解 tinnitus 的神经基础对于开发有效的治疗方法至关重要.

研究的目的:

研究 tinnitus 患者的动态神经活动模式,比较正常听力与听力障碍患者.
探索神经活动变化和临床症状 (如痛苦,焦虑和抑郁症) 之间的关系.

主要方法:

休息状态功能磁共振成像 (fMRI) 用于82名参与者 (对照组,听力正常的耳,听力受损的耳).
低频波动的动态振幅 (d-ALFF) 和动态区域同质性 (d-ReHo) 使用滑窗分析计算.
时间变异性使用变化系数进行评估,使用包括ANOVA和相关性在内的统计分析.

主要成果:

与对照组和听力受损的耳相比,听力正常的耳患者在小脑,状和尾区域显示d-ALFF变异性增加.
与对照组相比,这两组耳声在额头区域的d-ALFF变异性都减少了.
在这两组耳患者中,右侧前带带皮层中观察到d-ReHo可变性减少.

结论:

听力正常的耳与感官处理区域的超变性有关,与听力受损的耳不同.
额头区域和前带皮质神经活动变化减少可能代表一个常见的耳机制.
神经动力学及其与临床症状的相关性根据 tinnitus 患者的听力状况而有很大差异.

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