CD5阳性原发性皮肤扩散性大B细胞淋巴瘤,腿类型:一种不寻常的呈现
Anna A Kozyreva1, Ilya V Tsvetnov1, Kirill A Lyapichev2
1UNIM LLC, Moscow, Russia; and.
The American Journal of dermatopathology
|March 4, 2026
概括
CD5阳性原发性皮肤扩散性大B细胞淋巴瘤腿类型 (PCDLBCL-LT) 是罕见的. 这份病例报告详细介绍了一位患者的情况.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 皮肤病理学 皮肤病理学
背景情况:
- 初级皮肤扩散大B细胞淋巴瘤腿类型 (PCDLBCL-LT) 是一种侵略性的非霍奇金淋巴瘤.
- 在PCDLBCL-LT中CD5表达是罕见的,并使诊断复杂化,扩大差异包括其他B细胞淋巴瘤.
- 准确的诊断对于适当的患者管理和监测至关重要.
研究的目的:
- 在一位老年女性患者中报告CD5阳性PCDLBCL-LT的罕见病例.
- 突出这一独特的PCDLBCL-LT子组的诊断挑战和管理.
- 强调CD5检测在PCDLBCL-LT诊断中的重要性.
主要方法:
- 一个70岁的女性患有下肢皮肤结节的病例报告.
- 组织病理学和免疫组织化学分析,包括CD5,CD20,MUM1,BCL2,IgM和cyclin D1.
- 在MYC,BCL2和BCL6重新排列时进行光在位杂交 (FISH).
- 用R-CHOP化疗治疗,然后用修复剂-贝瓦西祖马布治疗复发.
主要成果:
- 组织病理学揭示了一种非典型的大型B细胞的pandermal扩散透.
- 免疫组织化学证实了CD5 +,CD20 +,MUM1 +,BCL2 +,IgM +,环素D1档案,支持CD5 + PCDLBCL-LT.
- 对于MYC,BCL2和BCL6重组,FISH结果是负的,排除了双击/三击淋巴瘤.
- 患者通过R-CHOP获得了初始完全反应,随后通过Rituximab-bevacizumab复发和第二次完全缓解.
结论:
- CD5阳性定义了一个独特的PCDLBCL-LT亚组,需要仔细的诊断考虑.
- 常规的CD5检测对于PCDLBCL-LT的准确诊断和差异诊断至关重要.
- 这一案例强调了对CD5+PCDLBCL-LT的警监测和量身定制的治疗策略的重要性.
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