相关实验视频

Updated: Mar 6, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

在免疫效应细胞治疗后,我如何治疗HLH类毒性?

William T Johnson¹, Kevin O McNerney², Matthew J Frank³

¹Memorial Sloan Kettering Cancer Center, New York, New York, United States.

|March 4, 2026

概括

癌症免疫疗法可以导致严重的毒性,如细胞因子释放综合征 (CRS) 和免疫效应细胞相关的HLH类综合征 (IEC-HS). 区分和管理这些高炎症综合征对于患者的治疗结果至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
血液学血液学血液学

背景情况:

癌症免疫治疗的进步,包括CAR T细胞,已经引入了新的毒性.
与治疗相关的血细胞性淋巴细胞瘤样毒性 (HLH) 被认为是超炎症综合征.
免疫效应细胞相关的HLH类综合征 (IEC-HS) 和多器官功能障碍的CRS (CRS-MOD) 是不同的,但难以区分.

研究的目的:

概述一种临床方法来管理CAR T细胞相关的HLH类毒性.
为了区分CRS-MOD和IEC-HS.
审查这些综合征的当前治疗策略.

主要方法:

临床病例审查和专家共识.
对CRS-MOD和IEC-HS.不同临床和时间特征的分析.
诊断标准和治疗干预措施的概述.

主要成果:

IEC-HS从CRS中明显出现,通常是在解决方案之后.
在恶化的CRS过程中,CRS-MOD呈现出类似HLH的特征.
区分这些综合征在临床上具有挑战性,但至关重要.

结论:

早期识别和干预HLH类毒性对于改善患者的治疗结果至关重要.
了解CRS-MOD和IEC-HS的独特病理生理学,可以为管理策略提供信息.
一个全面的诊断和治疗方法对于管理免疫疗法诱导的高炎症综合征至关重要.

更多相关视频

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Published on: April 11, 2011

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Published on: February 10, 2023

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...