在接受免疫抑制向治疗的人群中,免疫接种疫苗可预防疾病的免疫接种
Xia Wang1, Cyra Patel2, Ketaki Sharma3
1National Centre for Immunisation Research and Surveillance (NCIRS), Westmead, New South Wales, Australia.
Vaccine
|March 4, 2026
概括
向疗法具有可变的感染风险,并影响患者的疫苗反应. 淋巴细胞消耗治疗和其他免疫抑制剂增加了风险,需要对免疫受损的个体进行仔细监测和未来的研究.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 针对性疗法的使用不断扩大,使得预测感染风险和疫苗反应变得更加复杂.
- 临床医生在管理这些复杂治疗的患者时面临挑战.
研究的目的:
- 审查目前关于接受向治疗的患者感染风险,疫苗疗效和安全性的证据.
- 识别知识上的差距,并建议未来的研究方向.
主要方法:
- 对现有文献进行系统审查.
- 专注于感染风险,疫苗免疫性和安全数据.
- 分析影响结果的因素,包括同时服用的药物.
主要成果:
- 针对性疗法之间,感染风险和疫苗反应显著不同.
- 同时服用免疫抑制剂会增加严重感染的风险.
- 大多数疫苗数据集中在COVID-19,流感和肺炎球菌疫苗上;反应通常受到损害,但很少被消除.
- 活体疫苗的安全性是令人担忧的,尽管严重的不良事件很少发生.
结论:
- 向治疗改变了感染易感性和疫苗有效性,淋巴细胞减肥剂带来了更高的风险.
- 目前的证据受到研究设计的限制;未来的试验必须包括免疫受损人群.
- 预测模型和生物标志物的开发对于风险分层和疫苗有效性评估至关重要.
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