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Updated: Mar 6, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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优化基于三醇的Aha1/Hsp90复合物的小分子干扰剂,这些干扰物表现出强烈的活动

Kevin C Catalfano1, Margaret H Rakonick1, Brian S J Blagg1

  • 1Department of Chemistry and Biochemistry, Warren Center for Drug Discovery, The University of Notre Dame, 305 McCourtney Hall, Notre Dame, IN, 46556, USA.

European journal of medicinal chemistry
|March 4, 2026
PubMed
概括

研究人员优化了热冲击蛋白90 (Hsp90) /Aha1破坏者Triazole A,产生了强大的新分子. 这些化合物提供了改进的基于细胞的活性,并作为研究Hsp90/Aha1复合体的有价值的化学工具.

关键词:
哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈在 Hsp90 中,Hsp90 是小分子干扰剂 小分子干扰剂三醇是一种三醇.

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