早期病毒载量在预测SFTS预后方面优于细胞因子和淋巴细胞:一项动态免疫分析研究
Keping Chen1, Gan Cao2, Yurong Xu1
1Clinical Laboratory, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
概括
严重的发烧与血小板缺血综合征 (SFTS) 涉及细胞因子风暴和淋巴细胞枯竭. SFTS病毒载量是早期预后预测的优越生物标志物,其表现优于免疫标志物.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 严重发烧与血小板缺血综合征 (SFTS) 是一种新兴的传染病,死亡率高.
- 目前尚不完全了解SFTS的病理生理学.
- 了解SFTS免疫病原发生是改善患者预后的关键.
研究的目的:
- 为了研究SFTS患者的细胞因子和淋巴细胞反应.
- 为了评估这些免疫反应和病毒载荷的预后价值.
- 为了阐明SFTS的免疫病原发生.
主要方法:
- 纳入了96名SFTS患者.
- 细胞因子和淋巴细胞使用流动细胞计量量化.
- 使用后勤回归和ROC曲线来评估预后价值.
主要成果:
- IL-10与病毒载量正相关;T淋巴细胞负相关.
- SFTS病毒载量是最强的早期预后预测因素 (发病后4-6天).
- 后来,病毒载量,特定细胞因子 (IL-6,IL-10,IFN-γ) 和淋巴细胞计数预测了预后 (7-9天后).
结论:
- SFTS的发病包括细胞因子风暴和淋巴细胞枯竭.
- 病毒载量是早期SFTS预后预测的优越生物标志物.
- 免疫反应为SFTS病理生理学提供了洞察力.
相关概念视频
Myocarditis III: Medical Management
274
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
274
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
405
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
405
Types of Fever
1.4K
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Here are the different types of fever:
1.4K
Increased Body Temperature
7.6K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.6K
Acute Pyelonephritis II: Diagnostic Studies and Management
542
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
542
Myocarditis II: Clinical Features and Diagnostic Tests
392
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
392


