生物医学文本的自然语言处理用于绘制和优先考虑HFpEF中的蛋白质疾病关联
Clodomir Santana1, Chitra Mukherjee2, Arnib Quazi3
1Department of Medicine, Division of Cardiovascular Disease, University of California, Davis, USA.
Computers in biology and medicine
|March 4, 2026
概括
这项研究使用机器学习分析了数以百万计的生物医学摘要,识别了心血管疾病 (CVD) 的关键蛋白质,并揭示了心力衰竭与保留喷射分数 (HFpEF) 作为多系统性疾病.
科学领域:
- 生物医学信息学 生物医学信息学
- 计算生物学 计算生物学
- 心血管医学 心血管医学
背景情况:
- 庞大的生物医学文献阻碍了心血管疾病 (CVD) 中生物标志物和药物标的验证.
- 需要一种机器学习方法来导航和合成这种碎片化的文献.
研究的目的:
- 开发和应用一个文本挖掘框架 (VITAL) 来分析数百万的PubMed摘要.
- 识别和优先考虑心血管疾病的蛋白质疾病关联,重点关注心力衰竭与保留射出分数 (HFpEF).
主要方法:
- 使用基于机器学习的文本挖掘算法与自然语言处理 (NLP).
- 分析了超过3800万个PubMed摘要,确定了550万个与六个主要心血管疾病组相关的摘要.
- 进行了HFpEF的案例研究,分析了与并发症和病理机制的蛋白质关联.
主要成果:
- 确认已知的心血管疾病生物标志物和确定新的蛋白质特征.
- 在缺血性心脏病,心肌病和脑血管事故的蛋白质关联中发现了显著的重叠.
- 鉴定了5124种与HFpEF相关的蛋白质,其中许多与共患病和炎症和纤维化等病理机制共享.
- 顶级HFpEF蛋白候选者主要表达在非心脏组织 (肝脏,胰腺,脂肪) 中,支持多系统性疾病概念.
结论:
- 文本挖掘有效地注释,整合和优先考虑来自大型文献数据集的蛋白质疾病关系.
- HFpEF很可能是一种多系统性疾病,由器官间信号传递介导,而不仅仅是心脏疾病.
- 这种计算框架补充了对心血管疾病生物标志物发现和药物标识的omics方法.
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