在早期舌头癌症中出现和转移的舌头淋巴结:一种侵略性切除的指标
Zi-Li Yu1, Lei Chen2, Hai-Xiao Zou3
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, China; Department of Oral Maxillofacial and Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
概括
语言淋巴结 (LLN) 剖析可能会改善早期舌头癌症患者的生存率. 严重的LLN参与预测了更糟糕的结果,这表明更广泛的手术可能是有益的.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 头部和部癌症 头部和部癌症
背景情况:
- 由于高的局部区域复发率,早期舌头癌症的治疗很困难.
- 语言淋巴结 (LLN) 转移是影响预后的关键因素.
研究的目的:
- 评估LLN剖析对早期舌癌复发,整体存活率 (OS) 和无病存活率 (DFS) 的影响.
- 在这个患者群体中确定生存结果的预测因素.
主要方法:
- 对162名早期 (cT1-T2) 舌头SCC患者的回顾性分析.
- 进行LLN剖析的患者与没有进行LLN剖析的患者之间的结果比较.
- 卡普兰-梅尔生存分析和单变量/多变量分析.
主要成果:
- LLN剖析显示了与改善的OS和DFS的正相关性,尽管在统计学上并不显著.
- 患有LLN参与 (发生或转移) 的患者的OS和DFS明显恶化.
- 证实LLN参与是OS和DFS的独立风险因素.
结论:
- 在早期的舌癌中,LLN参与是生存的关键预测因素.
- 在手术期间检测到LLN参与,需要考虑更广泛的程序,如连续性部剖析,以改善结果.
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