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环境相关度的易布洛芬对大夫尼亚大的跨代影响

Yuanyuan Xiao¹, Weiqi Zhao¹, Chunni Duan¹

¹Department of Ecology, Jinan University, Guangzhou 510632, China.

Aquatic toxicology (Amsterdam, Netherlands)

|March 4, 2026

概括

布洛芬会对水生生物代代相继造成伤害,影响生长,繁殖和行为. 这些影响,包括表观遗传变化,即使暴露停止后也持续存在,突出显示了现实世界水生环境中的风险.

科学领域:

环境毒理学环境毒理学
生态毒理学生态毒理学
水生毒理学水生毒理学

背景情况:

布洛芬在水生生态系统中普遍存在.
对水生生物的潜在风险尚未完全理解.
跨代效应需要进一步研究.

研究的目的:

评估大夫尼亚大中布洛芬的跨代毒性.
调查一系列环境相关度的影响.
阐明潜在的分子和表观遗传机制.

主要方法:

多代暴露研究 (F0,F3C,F3R) 与大夫尼亚大.
暴露度在0.5至500μg/L之间.
分析包括生长,繁殖,行为,基因表达 (EcR,CYP314,VTG) 和全基因组双硫酸盐测序.

主要成果:

暴露于易布洛芬会影响大夫尼的生长,繁殖和游泳行为.
不良影响和形态形持续了几代人 (F3C和F3R).
观察到内分泌通路的干扰,线粒体失衡,氧化应激,以及特定世代的DNA甲基化模式.

结论:

伊布洛芬在大夫尼亚大中表现出显著的跨代毒性.
在环境现实的度下,可以测量不良影响.
表观遗传变化提供了多代影响的证据,为生态风险评估提供了信息.

关键词:

通过DNA甲基化.达夫尼亚大 (Daphnia magna) 是一个大的植物.伊布罗芬是什么意思?伊布罗芬是什么意思?线粒体动力学的动态跨代性毒性跨代性毒性

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