寻找可卡因的psilocybin和ibogaine:在没有复发预防的情况下增强灭绝
Isis Rita Anzel Koutrouli1,2, Vojtěch Brejtr1,3, Marek Schwendt4
1Psychedelic Research Centre, National Institute of Mental Health, Klecany, Czech Republic.
Addiction biology
|March 4, 2026
概括
像psilocybin和ibogaine这样的迷幻药物可以通过帮助老鼠的灭绝学习来帮助治疗物质使用障碍. 需要进一步的研究来证实它们的抗上潜力和复发预防效果.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 成研究 研究成研究
背景情况:
- 药物使用障碍 (SUD) 是一个主要的公共卫生问题.
- 迷幻药物,包括psilocybin和ibogaine,显示希望作为SUDs的新疗法.
- 在成模型中,关于迷幻药的疗效的临床前数据是有限的.
研究的目的:
- 为了研究psilocybin和ibogaine对灭和复发行为的影响,在可卡因自我管理的老鼠模型中.
- 为了评估一个临床灵感的剂量升级协议用于迷幻药的管理.
主要方法:
- 老鼠接受了可卡因自我管理 (IVSA) 的剂量升级.
- 收购后,老鼠经历了10天的灭绝训练.
- 在灭绝第1天和第5天,施用了psilocybin (1.25和5毫克/公斤) 或ibogaine (10和40毫克/公斤).
- 评估了由线索诱导的恢复和运动机动活动/焦虑.
主要成果:
- 西和伊博加因都调节了灭绝行为,伊博加因在第一剂后表现出效果,而西在第二剂后表现出效果.
- 两种迷幻药都没有显著改变暗示诱导的恢复,尽管psilocybin显示了减弱的趋势.
- 没有观察到对发动机活动或焦虑的显著副作用.
结论:
- 在使用可卡因的老鼠模型中,psilocybin和ibogaine促进了灭绝学习.
- 这些迷幻药可能提供预防复发的保护作用,支持它们作为抗上治疗的潜力.
- 需要进一步研究psilocybin和ibogaine的抗上功效.
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