在ECHO队列中,产前感知压力与儿童自闭症相关特征之间的关联
Luke P Grosvenor1, Monica McGrath2, Jasmine Douglas2
1Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.
The Journal of pediatrics
|March 4, 2026
概括
产前感知压力显示了与儿童自闭症相关特征增加的小但重要的关联. 这些联系在男性中略有强烈,但并没有被产前抑郁症状显著改变.
科学领域:
- 儿童发展 儿童发展
- 神经发育障碍 神经发育障碍
- 产前健康 产前健康
背景情况:
- 产前压力是神经发育结果的潜在环境风险因素.
- 与自闭症相关的特征可以在早期表现出来,并受到各种遗传和环境因素的影响.
- 了解产前影响对于早期识别和干预策略至关重要.
研究的目的:
- 为了研究母亲在怀孕期间感知到的压力和儿童自闭症相关特征之间的关系.
- 探索儿童性行为或同时出现的产前抑郁症状是否会改变这种关联.
主要方法:
- 利用了来自4,115个母婴对的环境影响儿童健康结果 (ECHO) 队列的数据.
- 使用感知压力量表 (PSS) 评估产前感知压力.
- 用社会响应度量 (SRS-2) 测量儿童自闭症相关特征,并使用回归模型分析关联.
主要成果:
- 更高的产前感知压力 (PSS) 与自闭症相关特征的严重程度增加 (β=0.15) 和中度至严重特征的更高几率 (OR=1.04) 相关.
- 对连续性特征 (P=0.03) 观察到显著的性与暴露相互作用,男性的相关性更强.
- 根据产前抑郁症状水平 (P=0.66),相关性没有显著差异.
结论:
- 产前感知压力与儿童的自闭症相关特征有关.
- 这种关联在男孩中似乎略有强烈.
- 有限的证据表明,产前压力会影响自闭症相关的特征,独立于产前抑郁症状.
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