对抗癌症治疗的非侵入性输送策略的进展
Ling Zou1, Xiang You1, Jingjing Ma1
1Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
概括
与注射相比,非侵入性抗癌药物输送系统可以改善患者的服药性,减少副作用. 本综述探讨了提高癌症治疗疗效的各种非侵入性途径.
科学领域:
- 在瘤学瘤学.
- 制药科学 制药科学
- 生物医学工程 生物医学工程
背景情况:
- 抗癌药物面临着诸如瘤积累不良,有效性有限和不良反应等挑战,往往需要侵入性输送方法.
- 侵入性途径,主要是注射,导致生物可用性问题,并损害患者的耐受性,特别是在长期癌症治疗中.
- 显著需要非侵入性抗癌策略,这些策略可以增强药物输送和瘤向,同时改善患者的坚持.
研究的目的:
- 审查非侵入性抗癌药物输送策略的临床相关性.
- 概述与不同非侵入性施用途径相关的解剖和生理障碍.
- 讨论有效的非侵入性癌症治疗的最新进展和设计考虑.
主要方法:
- 对用于癌症治疗的非侵入性药物输送系统的文献综述.
- 对口腔,鼻腔,肺部,口腔粘膜和透皮通道的解剖学和生理障碍的分析.
- 检查最近的进步和设计原则的非侵入性交付配方.
主要成果:
- 非侵入性途径 (口腔,鼻腔,肺,口腔,透皮) 显示出改善生物可用性和瘤向性的承诺.
- 了解和克服路线特定的障碍对于成功的非侵入性药物输送至关重要.
- 最近的创新重点是通过新的配方设计来提高药物的疗效,生物相容性和患者的遵守性.
结论:
- 非侵入性抗癌药物输送系统为癌症治疗提供了以患者为中心的方法.
- 这些策略有可能克服传统侵入性方法的局限性,减少副作用并改善治疗结果.
- 进一步的研究和开发对于先进的非侵入性输送系统的临床转化至关重要.
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