饮食中的有机硫化合物和H2S-多硫化物逆氧轴:当前证据和局限性
Nikky Sharma1, Tejasvi Pandey1, Vivek Pandey2
1Department of Forensic Sciences, School for Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India.
The Journal of nutritional biochemistry
|March 4, 2026
概括
来自蔬菜和氨基酸的食有机硫化合物 (OSC) 影响硫代谢和反应性硫种 (RSS) 信号. 研究探讨了它们在蛋白质修饰和氧化还原平衡中的作用,以及潜在的健康益处.
科学领域:
- 营养生物化学 营养生物化学
- 转毒生物学 转毒生物学
- 分子营养分子营养学
背景情况:
- 食中的有机硫化合物 (OSC) 是来自和菜类蔬菜等食物中的含硫分子.
- OSCs因其与内源硫代谢和活性硫物种 (RSS) 相互作用的潜力而得到认可.
- 新出现的证据表明,OSCs影响硫化 (H2S) 和反应性聚硫化生物学.
研究的目的:
- 审查营养OSC的化学多样性,食来源和生物可用性.
- 检查胃肠道新陈代谢,微生物转化和醇反应如何影响OSC的生物命运.
- 综合有关OSCs对内源H2S和多硫化物生成以及相关信号通路的影响的发现.
主要方法:
- 文献综述综合化学,细胞和临床前研究OSCs.
- 对OSC代谢和RSS生成的拟议生物化学途径的检查.
- 对OSCs对蛋白质固硫化,线粒体氧化还原调节和Nrf2信号传递的影响进行分析.
主要成果:
- OSCs表现出多样化的结构和食来源,其生物可用性受到加工和新陈代谢的影响.
- 拟议的途径通过酶和非酶反应将OSC摄入与内源H2S和聚硫化物生产联系起来.
- OSCs调节蛋白质固硫化,线粒体氧化还原状态和Nrf2信号,影响细胞氧化还原平衡.
结论:
- OSCs在调节内源硫信号通路,特别是H2S和多硫化物中发挥着重要作用.
- 在氧化还原生物学上,OSC介导的影响对氧化应激,代谢调节和免疫恒温有潜在的影响.
- 需要进一步对人类进行研究,以充分阐明OSCs在氧化还原生物学中的营养和治疗潜力.
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