基阻燃剂,甲状腺功能生物标志物,注意力缺陷/过度活动障碍相关特征和儿童的神经发育:加拿大前性出生队列研究的最新证据
Yihan Fan1, Yike Shen2, Yidan Zhang2
1Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, 90095, USA.
Environmental research
|March 4, 2026
概括
素阻燃剂 (HFRs) 通过改变甲状腺激素,可能会影响儿童的神经发育. 虽然在HFR,甲状腺刺激激素 (TSH) 和神经发育结果之间观察到一些关联,但经过调整后的结果在统计学上并不显著,这表明需要更多的研究.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 神经发育科学 神经发育科学
背景情况:
- 原阻燃剂 (HFRs) 是环境污染物,与潜在的内分泌干扰有关.
- 甲状腺激素平衡对于神经发育至关重要,HFRs可能会干扰这个过程.
- 关于多矩阵HFR暴露,甲状腺功能和儿童综合神经发育结果的研究有限.
研究的目的:
- 调查儿童中HFR暴露和甲状腺功能生物标志物之间的关联.
- 检查甲状腺功能生物标志物与神经发育结果之间的关系.
- 评估甲状腺功能生物标志物作为HFR神经发育途径的潜在调解者.
主要方法:
- 来自前性GESTation和环境 (GESTE) 出生队列的数据的横截面分析.
- 测量血和便HFRs,血甲状腺刺激激素 (TSH) 和神经发育结果 (ADHD特征,认知测试,fMRI).
- 包括回归和调解模型在内的统计分析,并对多重比较进行调整.
主要成果:
- 较高的血BDE-153与较低的TSH相关;较高的便BDE-47与较高的TSH相关.
- 较高的TSH水平与区块设计测试中的表现较差以及改变的默认模式网络连接相关.
- 调解分析表明,TSH与便BDE-47联系的潜在间接效应可以阻止设计得分.
- 在控制错误发现率后,所有观察到的关联都失去了统计意义.
结论:
- 虽然HFRs,甲状腺功能和儿童神经发育之间存在潜在的联系,但这些发现并不强大.
- 高频回路和神经发育之间的复杂关系需要进一步研究,采用更大的样本大小和纵向设计.
- 目前的证据不足以证实HFRs通过甲状腺激素干扰对神经发育的影响.
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