基于液晶的生物传感器用于临床诊断
Qamar Abuhassan1, Jamal I Al-Nabulsi2, Subbulakshmi Ganesan3
1Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, University of Jordan, Amman, 11942, Jordan.
概括
液晶 (LC) 生物传感器提供敏感的,无标签的疾病生物标志物的检测. 本综述探讨了LC生物传感器原理,用于诊断癌症,糖尿病和感染的应用,以及未来的商业潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 光学是什么?光学是什么?光学是什么?
背景情况:
- 液晶 (LCs) 具有独特的光学特性,对分子相互作用敏感.
- 基于LC的生物传感器利用LC的方向变化在信号转导的生物标志物结合时.
- 现有的诊断方法在灵敏度,成本和速度方面面临挑战.
研究的目的:
- 提供基于LC的生物传感器技术的全面审查.
- 研究LC生物传感器的基本原理,材料科学和光学检测方法.
- 讨论临床诊断中LC生物传感器的应用,进展和未来潜力.
主要方法:
- 审查基本的LC材料科学和光学检测原则.
- 分析LC生物传感器用于检测癌症,糖尿病,神经系统疾病和传染病的应用.
- 讨论最近在检测蛋白质,核酸和小分子方面的进展.
主要成果:
- LC生物传感器表现出高灵敏度和无标签检测能力.
- 生物分子结合事件有效地扰乱LC的方向,产生可检测的光学信号.
- LC生物传感器显示出早期和准确的疾病诊断的前景.
结论:
- 液晶生物传感器是生物标志物检测的多功能和强大的平台.
- 在LC生物传感器设计的进步提高了灵敏度,并使无标签的诊断.
- 对于LC生物传感器在诊断领域的未来开发和商业化,存在巨大的潜力.
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