基于HS15的纳米治疗药物用于直接鼻至大脑输送,对抗中枢神经系统的真菌菌
Gaoshuo Zhang1, Xingwang Ji1, Wei Zhang1
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, PR China.
Journal of pharmaceutical sciences
|March 4, 2026
概括
使用HS15-LC纳米复合物的鼻到脑输送安福特里B (AmB) 为治疗真菌中枢神经系统感染提供了一个有前途的策略. 这种方法可以提高大脑药物度,同时最大限度地减少系统毒性和副作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术 纳米技术
- 神经科学是一个神经科学.
背景情况:
- 氨酸B (AmB) 对真菌感染有效,但在中枢神经系统治疗方面受到血脑屏障 (BBB) 和毒性的限制.
- 系统性AMB的使用会导致严重的副作用,阻碍其用于治疗大脑感染.
- 鼻到脑的输送提供了一种非侵入性的途径,通过嗅觉和三角管路径绕过BBB.
研究的目的:
- 构建和评估HS15-莱西-胆固醇 (HS15-LC) 纳米复合体,用于鼻内输送安特素B (AmB).
- 评估鼻入脑输送AmB用于治疗中枢神经系统 (CNS) 真菌感染的可行性.
- 优化HS15-LC配方,以增强大脑向性和降低系统毒性.
主要方法:
- 制备HS15-LC纳米复合物用于AMB封装.
- 基于封装效率的最佳HS15-LC配方的选.
- 纳米复杂粒子大小,潜力和稳定性的表征.
- 在体外和体内研究评估药物释放,大脑分布和毒性.
主要成果:
- 最佳的HS15-LC配方在AMB加载后显示出稳定的颗粒大小和潜力.
- 鼻喷雾配方在各种条件下 (放置,稀释,喷) 呈现出良好的稳定性.
- 在体内和体外的研究证实了AMB的延长和增强的脑内分布.
- 组织病理学分析显示,粘膜和脏有毒性最小,这表明了有利的安全性.
结论:
- 通过HS15-LC纳米复合体注射AmB是中枢神经系统真菌感染的可行和有效策略.
- 这种方法成功地提高了大脑的药物输送,克服了BBB的局限性并减少了全身毒性.
- 开发的配方为治疗耐火性真菌脑膜炎和其他中枢神经系统真菌疾病提供了一个有希望的替代方案.
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