免疫抑制治疗在复发性自身免疫性胰腺炎中的有效性和安全性
Yusuke Kurita1, Kensuke Kubota1, Ryusuke Yoshimi2
1Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Japan.
Internal medicine (Tokyo, Japan)
|March 4, 2026
概括
免疫抑制剂可能有助于在日本患有耐火性自身免疫性胰腺炎 (AIP) 的患者中维持缓解. 然而,由于潜在的不良事件和恶性瘤风险,仔细监测至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性胰腺炎 (AIP) 是一种对葡萄糖皮质类药物反应的慢性胰腺炎.
- 在一些AIP患者中,经常出现复发或葡萄糖皮质类药物依赖.
- 对于亚洲AIP患者的免疫抑制剂的证据有限.
研究的目的:
- 在日本患者中评估耐火性AIP的免疫抑制剂的疗效和安全性.
- 评估缓解率,不良事件和恶性瘤发生率.
主要方法:
- 对12名日本1型AIP患者的回顾性分析,这些患者多次复发,接受免疫抑制疗法.
- 评估临床缓解,不良事件和恶性瘤发生率.
主要成果:
- 9名患者中有8名 (88.9%) 在免疫抑制剂 (阿扎西奥普林,塔克罗利斯,甲铁酸盐) 中保持了临床缓解.
- 三名患者 (25.0%) 因不良事件而停止治疗.
- 在随访期间,两名患者出现恶性瘤 (淋巴瘤,肺癌).
结论:
- 免疫抑制疗法可以帮助维持耐药AIP的缓解,包括在日本患者.
- 副作用和恶性瘤风险需要仔细选择和监测患者.
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