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Updated: Jul 1, 2026

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第Ib期研究评估新辅助剂trifluridine/tipiracil与可切除II/III期直肠癌的同时辐射的安全性:FIERCE研究

Emerson Y Chen1, Nima Nabavizadeh2, Nicholas D Kendsersky1

  • 1Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.

Clinical colorectal cancer
|March 4, 2026
PubMed
概括

三氨/提皮拉西尔 (FTD/TPI) 是安全的和可行的作为整体新辅助疗法用于直肠癌. 确定最大耐受剂量为35mg/m2,显示了有希望的器官保存功效信号.

关键词:
化学疗法或放射疗法临床试验临床试验是指临床试验的临床试验.局部发达的直肠癌 局部发达的直肠癌氧化酸是一种氧化酸.总的新辅助疗法治疗.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...