在焦虑症中皮层厚度的变化及其与基于Atlas的神经递质地图的关联
1Department of Radiology, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China (L.W., R.L., L.Z., H.L.).
Academic radiology
|March 4, 2026
概括
焦虑障碍 (ADs) 与特定区域的大脑皮层厚度 (CTh) 的改变有关,特别是左前中心和岛屿. 这项研究将这些结构变化与神经递质系统相关联,为ADS提供了洞察力.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 焦虑症 (ADs) 与大脑区域的皮层厚度 (CTh) 发生变化有关,但研究结果不一致.
- 在ADs中,结构性大脑变化的分子基础在很大程度上是未知的.
研究的目的:
- 在ADS患者中识别一致的CTh变化.
- 描述这些结构变化的基础分子特征.
主要方法:
- 使用异型效应大小基于种子的d绘图 (AES-SDM) 软件进行的元分析.
- 使用JuSpace工具箱进行神经递质分布和CTh变化之间的空间相关性分析.
主要成果:
- 对9项研究的元分析 (264名AD患者,286名HC患者) 显示,AD患者的左前中心 (PreCG) 和左侧胰岛的CTh增加.
- 在ADs中观察到右上额头的背侧区域的CTh降低.
- 左侧PreCG的CTh变化与年龄和男性百分比相关;与血清,GABAergic,胆和谷氨酸性神经递质相关的模式.
结论:
- 在AD中异常的CTh与特定的神经递质系统有关,进步对形态变化及其分子基础的理解.
- 研究结果表明,ADs可能是潜在的治疗目标.
- 这些初步结果需要在更大的多模式研究中进行验证.
更多相关视频
06:26Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
78.3K
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.9K
相关概念视频
01:30Attention-Deficit/Hyperactivity Disorder
1.1K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.1K
01:18Anxiety: Overview
1.2K
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
1.2K