相关实验视频

Updated: Mar 6, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

在活体捐赠者肝移植中对面板反应性抗体的评估

Huseyin Kocaaslan¹, Tevfik Tolga Sahin¹, Sami Akbulut¹

¹Department of General Surgery and Institute of Liver Transplantation, University of Inonu, Malatya, Turkiye.

Transplantation proceedings

|March 4, 2026

概括

肝移植后面板反应性抗体 (PRA) 水平没有显著变化,这表明单独进行PRA测试可能无法可靠地诊断急性抗体中介排斥 (AMR). 建议在AMR诊断时与其他标准一起进行进一步评估.

科学领域:

移植免疫学移植免疫学
胃肠病学胃肠病学
临床诊断临床诊断临床诊断

背景情况:

急性抗体中介排斥 (AMR) 是肝移植的一种罕见但严重的并发症,可能导致移植损失.
抗胰岛素耐药性可能是预先形成的抗捐赠者抗体,ABO不兼容性或de novo抗体造成的.
移植前后评估小组反应性抗体 (PRA) 水平被探索为AMR的诊断工具.

研究的目的:

评估小组反应性抗体 (PRA) 测试在肝移植后识别急性抗体中介排斥 (AMR) 的诊断实用性.
在肝移植接受者中比较手术前和手术后的PRA I类和II类水平.

主要方法:

分析了连续70名活体供体肝移植患者.
根据术后肝功能测试 (LFT) 趋势,患者被分组.
术前和术后的PRA水平使用统计测试进行了比较 (曼-惠特尼U,Chi-square,Wilcoxon签名排名).

主要成果:

在手术后期与手术前期的小组反应性抗体 (PRA) I 类水平中没有观察到统计学上显著的差异 (p = .363).
同样,手术后的PRA II类水平与手术前水平相比没有统计学上显著的变化 (p = .721).
观察到的PRA水平的变化与临床结果或AMR诊断没有一致的相关性.

结论:

移植后肝功能检测的升高需要考虑排斥,包括AMR.
虽然PRA测试是AMR诊断工作的一部分,但PRA水平的变化可能并不总是与诊断相关.
应将PRA结果与其他诊断标准一起解释,以准确诊断AMR.

更多相关视频

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry

Published on: April 19, 2017

相关概念视频

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...