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Updated: Mar 6, 2026

Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
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TDP-43酸化:探索神经退行症中的激酶,酸酶和治疗潜力

Liti Zhang1, Yichen Huang2, Wei Huang1

  • 1Department of Biochemistry and Molecular Biology, School of Medicine, Key Laboratory of Neuroregeneration and Ministry of Education of Jiangsu, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu, China.

Journal of Alzheimer's disease : JAD
|March 4, 2026
PubMed
概括

异常的TARDNA结合蛋白43 (TDP-43) 酸化通过形成有毒聚合物驱动神经退行. 针对TDP-43酸化的疗法在治疗ALS和FTD等疾病方面表现有前途.

关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.在TDP-43中使用.神经退行性疾病是一种神经退行性疾病.酸酶是一种酸酶.酸化的方法是光化.蛋白质激酶酶是一种蛋白质激酶.

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