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EXPRESS:使用口服雷梅西维尔或GS-441524治疗非流动性猫类传染性腹膜炎:一种随机,双盲非劣势性试验

Terza Brostoff¹, Jully Pires², Amy Rose²

¹Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California at Davis, Davis, CA, USA.

Journal of feline medicine and surgery

|March 4, 2026

概括

口服雷梅西维尔和GS-441524是猫感染性炎 (FIP) 的有效治疗方法. 这两种核酸相似物在治疗猫的非流动性FIP方面都表现有前途,尽管长期复发需要进一步研究.

科学领域:

兽医医学兽医医学兽医医学
病毒学病毒学
药理学药理学是指药理学的学科.

背景情况:

猫传染性腹膜炎 (FIP) 是一种由猫冠状病毒引起的致命疾病.
核类比的GS-441524是一种常见的FIP抗病毒药物,也是remdesivir的母核.
雷梅西维尔是FDA批准的人类COVID-19的药物,并用于FIP的辅助.

研究的目的:

为了比较口服雷梅西维尔与GS-441524的疗效,作为非流动性FIP的猫的第一线抗病毒疗法.
进行前性,随机,双盲,非劣等性临床试验.
评估生存,无病缓解和长期结果.

主要方法:

患有非排泄性FIP的猫被随机分为两组.
一组接受了口服雷梅西维尔 (38-42mg/kg每天84天).
另一组接受了口服GS-441524 (18-22mg/kg每天84天),随访时间为6,16周和1.5-2年.

主要成果:

在16周后,90%的接受雷梅西维尔治疗的猫和70%的接受GS-441524治疗的猫活着,处于缓解状态.
在治疗期间的死亡发生在早期 (11天内).
长期随访表明,4只猫 (每组2只) 可能出现晚期复发.

结论:

无论GS-441524和remdesivir都是有效的治疗方法,用于非流动性FIP.
需要进一步的研究来了解和管理治疗猫的晚期复发率.
这些发现支持在FIP管理中使用这两种抗病毒药物.

关键词:

猫科动物的新冠病毒病毒.抗病毒疗法是一种抗病毒疗法.神经学 FIP 的 FIP 的 FIP.核酸类比的核酸类比眼睛的 FIP FIP 的

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