酸通过抑制DON诱导的铁灭菌来对抗脱氧尼瓦伦醇毒性
Haorong Wang1,2,3, Jiacui Xu1,2,3, Jinghan Feng1,2,3
1College of Animal Science, Jilin University, Changchun, Jilin, China.
NPJ science of food
|March 4, 2026
概括
酸 (GA) 通过抑制铁亡,有效地对抗家禽中脱氧烯 (DON) 毒性. 这项研究突出了GA的重点.
科学领域:
- 动物科学动物科学
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 脱氧尼瓦伦醇 (DON) 是一种广泛传播的真菌毒素,影响牲畜和家禽的健康.
- 聚醇正在研究其减轻菌毒素毒性的潜力.
- 酸 (GA) 成为抵消DON效应的有希望的候选人.
研究的目的:
- 在家禽模型中评估酸 (GA) 在减轻脱氧尼瓦伦醇 (DON) 毒性的疗效.
- 阐明GA对DON诱导损伤的保护作用的潜在分子机制.
- 探索GA在保护动物健康和食品安全免受菌根毒素污染方面的潜力.
主要方法:
- 使用胚胎纤维细胞进行体外研究,以评估细胞活力和氧化应激.
- 在身上进行体内研究,以评估DON引起的肝脏和肠道损伤.
- 转录和生化分析,以确定受DON和GA影响的分子通路.
- 检测铁的稳态,脂质过氧化和Nrf2通路的激活.
主要成果:
- DON暴露显著降低了细胞活力和诱导氧化应激,而GA联合治疗恢复了活力.
- 在小中,DON引起肝损伤和肠缩,而GA改善了这种情况.
- 通过破坏铁稳态和脂质过氧化,DON触发铁;GA激活Nrf2通路,上调细胞保护基因 (GPX4,FTH1,SLC7A11,HO-1),以抑制铁.
结论:
- 酸主要通过通过Nrf2通路激活抑制铁化来对抗脱氧尼瓦伦醇毒性.
- 这项研究提供了对GA对DON诱导损害的保护作用的机制性理解.
- GA显示了独立应用和组合疗法的潜力,以减轻畜牧业和食品安全中的真菌毒素风险.
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