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Updated: Mar 6, 2026

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
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通过dCas12f-σE-RNAP复合体进行RNA引导转录的结构基础

Renjian Xiao1, Florian T Hoffmann2,3, Dan Xie1

  • 1Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.

Nature
|March 4, 2026
PubMed
概括

这项研究揭示了CRISPR-Cas系统 (dCas12f-σE) 如何激活细菌基因转录. 由RNA引导的DNA结合招募RNA聚合酶,通过与传统促进体识别不同的新机制启动转录.

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