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Updated: Mar 6, 2026

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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Published on: October 18, 2022

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已发现的CRISPR-Cas12f同类驱动RNA引导的转录

Florian T Hoffmann1,2, Tanner Wiegand1,3, Adriana I Palmieri1

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.

Nature
|March 4, 2026
PubMed
概括

研究人员发现了一种新的RNA引导基因激活机制,使用细菌Cas12f蛋白和sigma-E因子. 这种系统使得无需传统的促进子序列的可编程转录成为可能,为基因调节提供了新的可能性.

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