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Updated: Mar 6, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

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一个依赖于乙化的开关是链球菌感染期间宿主疾病耐受性的基础

Sumit Kumar Paudel1, Sowmya Gannavaram1, Michael G Caparon2

  • 1Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, 25755, WV, USA.

Scientific reports
|March 4, 2026
PubMed
概括

菌 pyogenes pyruvate dehydrogenase (PDH) 通过改变新陈代谢和表观遗传调节来操纵宿主免疫力. 这项研究揭示了细菌PDH如何通过代谢和表观遗传交叉影响疾病耐受性 (DT).

关键词:
链球菌 pyogenes 的情况.乙-甲酸是一种对疾病的耐受性.希斯脱乙酶的使用免疫代谢过程中的免疫代谢.皮鲁酸盐脱酶的使用方法短链脂肪酸 短链脂肪酸

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