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Updated: Mar 6, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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托法西替尼修复了GM-CSF重编程的RA巨细胞中的炎症和线粒体失调

Neha Satoeya1,2, Stephanie R Zack1,2, Osama Al Zoubi1,2

  • 1Jesse Brown VA Medical Center, Chicago, IL, USA.

Cellular & molecular immunology
|March 4, 2026
PubMed
概括

托法西提尼有效向风湿性关节炎 (RA) 中的GM-CSF巨细胞,通过抑制STAT5信号,逆转炎症和线粒体损伤. 与其他疗法不同,它恢复了这些细胞中的调节性表型,为RA患者提供了一个有前途的治疗途径.

关键词:
转基因-CSFF的时间巨细胞是一个巨细胞.线粒体碎片化的分裂在 NFIL3 中.氧化应激是一种氧化应激.

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