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贝叶斯定序格子设计用于I期临床试验

Gi-Ming Wang1, Curtis Tatsuoka2

  • 1Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.

Statistics in medicine
|March 4, 2026
PubMed
概括

我们介绍了贝叶斯有序格子设计 (BOLD),这是早期I期临床试验的新框架. BOLD有效地使用先前的毒性数据和剂量排序来准确确定最大可容忍剂量 (MTD).

关键词:
贝叶斯式设计 贝叶斯式设计选择剂量选择剂量选择在早期的第一阶段临床试验中.格子 格子 格子 格子最大的可容忍剂量.订单是为了订单.

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