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Updated: Mar 6, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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蛋白质稳定中的GCN2:结构逻辑,信号网络和疾病

JiaYi Zhu1,2, Stefan J Marciniak1,2,3

  • 1Cambridge Institute for Medical Research (CIMR), University of Cambridge, UK.

The FEBS journal
|March 4, 2026
PubMed
概括

综合应激反应 (ISR) 激酶GCN2通过平衡蛋白质合成和降解来维持细胞健康. 失调的GCN2活性与疾病有关,使其成为恢复蛋白质稳定性的治疗点.

关键词:
在 GCN2 中.氨基酸感应是一种氨基酸感应.综合应激反应综合应激反应蛋白质稳定性 蛋白质稳定性翻译控制的翻译控制

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