多发性硬化症患者的个人内认知变异性,自我报告的认知功能障碍和功能困难之间的关系:初步调查
Kaitlin E Riegler1, Lindsay O Neto2,3, Aaron P Turner4,5
1RWJ Barnabas Health Medical Group, Multiple Sclerosis Care Center, Livingston, NJ, USA.
Journal of clinical and experimental neuropsychology
|March 5, 2026
概括
多发性硬化症 (pwMS) 患者的个人内认知变化 (IIV) 与较少的自我报告的记忆问题有关,但并不意味着性能. 增加的IIV可能表明认知能力下降,有助于早期干预.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 临床神经学 临床神经学
背景情况:
- 个体内认知变化 (IIV) 可能标志着微妙的认知障碍,并预测未来的衰退.
- 在多发性硬化症患者 (pwMS) 中了解IIV对于早期发现认知困难至关重要.
研究的目的:
- 调查IIV,自我认知的认知问题和pwMS中的功能限制之间的关系.
- 探索IIV的不同测量与认知表现和主观报告的相关性.
主要方法:
- 评估IIV使用11个神经心理测试的个体内标准偏差 (ISD),最大差异得分 (MDS) 和方差系数 (CoV).
- 对35名pwMS进行感知缺陷问卷 (PDQ),日常认知能力测试 (TECA) 和功能记忆问卷.
- 利用了部分斯皮尔曼相关性,控制了病前功能或症状评级.
主要成果:
- 增加的IIV (ISD,Cov) 与较少的自我报告的功能性记忆问题和较少的认知功能障碍相关.
- 在控制症状时,PDQ得分与IIV测量 (MDS,ISD) 有关.
- 与IIV (CoV,ISD) 和平均表现相关的TECA表现,表明有关认知能力的混合发现.
结论:
- 在pwMS对功能困难的感知与客观认知措施之间存在差异.
- IIV,而不是平均表现,似乎与pwMS的主观认知投诉有关.
- 对IIV的进一步研究对于开发PwMS认知问题的早期识别和干预策略至关重要.
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