达尔巴万辛诱导的白细胞结合性血管炎:一个病例报告
Vincenzo Scaglione1, Marco Cola1, Lolita Sasset1
1Infectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy.
The American journal of case reports
|March 5, 2026
概括
达尔巴万辛是一种治疗严重感染的抗生素,很少会导致白细胞结晶性血管炎 (LV). 本病例报告详细介绍了一名在达尔巴万辛治疗后患有LV的患者,强调了临床医生需要监测的潜在不良影响.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 达尔巴万辛是一种有效对抗包括MRSA在内的グラム阳性细菌的脂糖类抗生素.
- 它提供了好处,如每周一次的剂量和对复杂感染的良好耐受性.
- 这项研究侧重于对达尔巴万的罕见不良反应.
研究的目的:
- 报告第一个经组织学确认的白细胞结晶性血管炎 (LV) 病例,该病例是在达尔巴万辛治疗后出现的.
- 提高临床医生对这种潜在不良影响的认识.
主要方法:
- 一个66岁的女性患者的病例报告,她因急性细菌性皮肤和皮肤结构感染 (ABSSSI) 接受了dalbavancin治疗.
- 临床观察症状,包括明显的紫,关节痛和喘息.
- 皮肤活检的组织病理学检查,以确认白细胞结合性血管炎.
主要成果:
- 达尔巴万辛注射后三周,患者在下肢上出现了明显的紫外线.
- 皮肤活检证实了白细胞结合性血管炎 (LV).
- 皮质类固醇治疗导致显著的症状改善.
结论:
- 这是第一个在达尔巴万辛治疗后经组织学确认的LV病例.
- 临床医生应警LV作为达尔巴万辛的潜在不良影响,特别是在患有ABSSSI的患者中.
- 由于达尔巴万辛的广泛使用,对这种副作用的认识至关重要.
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