日本儿童的前列腺素E主要尿代谢物值与年龄相关的变化
Takatoshi Maeyama1, Ayaka Takashiba2, Ayaha Hata1
1Department of Gastroenterology, Nutrition, and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan.
概括
这项研究在健康儿童中确定了前列腺素E主要尿代谢物 (PGE-MUM) 的正常参考值. 研究结果显示,年幼儿童的PGE-MUM水平较高,这对于在儿科性结肠炎中准确解释生物标志物至关重要.
科学领域:
- 生物标志物发现和验证
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠道疾病研究研究
背景情况:
- 前列腺素E主要尿代谢物 (PGE-MUM) 是一种新兴的非侵入性生物标志物,用于评估炎症性肠病 (IBD) 的活性.
- 以前的研究将PGE-MUM与儿科性结肠炎 (UC) 中的结肠炎有关.
- 在健康儿童中正常的PGE-MUM参考值以前是未定义的.
研究的目的:
- 为了确定健康儿科患者PGE-MUM的正常参考值.
- 确定儿童PGE-MUM的特定年龄和性别的参考范围.
- 为使用PGE-MUM作为儿科IBD中的生物标志物提供基线.
主要方法:
- 一项前性横截面研究招募了221名年龄在0-15岁的健康儿童.
- 参与者没有炎症症状,并具有正常的C-反应蛋白水平.
- 通过化学发光酶免疫测试测量PGE-MUM;分析年龄和性别差异.
主要成果:
- 幼儿 (2-6岁) 的基准范围为18.4-58.7μg/g·Cr,较大的儿童 (7-14岁) 的基准范围为12.4-50.3μg/g·Cr.
- PGE-MUM值显示了随着年龄的增长而下降的趋势.
- 在PGE-MUM水平中没有观察到与性别相关的显著差异.
结论:
- 健康的儿童,特别是2-6岁的儿童,比健康的成年人表现出更高的PGE-MUM值.
- 在儿童群体中,PGE-MUM的年龄相关变异性是显著的.
- 这些发现需要在解释儿科UC的PGE-MUM时考虑特定年龄的范围.
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