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新兴的内源性Apelin 13在糖尿病及其相关并发症中:叙述性综述

Saurav Singla¹, Uma Jyoti¹, Thakur Gurjeet Singh¹

¹Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab.

Expert opinion on therapeutic targets

|March 5, 2026

概括

阿佩林-13通过提高胰岛素敏感性和血管健康来改善糖尿病的治疗. 它针对关键路径来减少炎症,氧化应激和器官损伤,提供新的治疗途径.

科学领域:

内分泌学在内分泌学.
心血管研究研究心血管研究
代谢障碍代谢障碍代谢障碍

背景情况:

胰岛素系统及其Apelin-13对于维持葡萄糖平衡,胰岛素敏感性和血管稳定性至关重要.
糖尿病及其并发症对全球健康构成重大挑战,需要新的治疗策略.

研究的目的:

审查Apelin-13在治疗糖尿病和相关疾病方面的治疗潜力.
探索阿佩林-13的作用背后的分子机制和信号通路.

主要方法:

在PubMed,Scopus和Web of Science进行了全面的文献搜索.
包括专注于Apelin-13在糖尿病,并发症,分子过程和信号通路中的作用的研究.

主要成果:

阿佩林-13通过PI3K/Akt,AMPK和eNOS通路增强胰岛素信号传递,葡萄糖吸收和内皮功能.
它减轻氧化应激和炎症 (SIRT1/PGC-1α轴),心脏重塑 (TGF-β/Smad,NF-κB) 和纤维化 (AMPK介导的自).
阿佩林-13还调节VEGF和TNF-α,以减少血管泄漏和神经炎症.

结论:

在糖尿病和相关并发症的临床前模型中,Apelin-13显示出显著的治疗潜力.
它对新陈代谢,血管,心脏和脏系统的多方面的作用突出显示了它作为一种新的治疗策略的承诺.

关键词:

在APJ受体.申诉人13号的申诉在PI3K/Akt.胰岛素耐药性是一种胰岛素耐药性.氧化应激是一种氧化应激.的β细胞.

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