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德克斯梅德托米丁在手术期间在异氨酸或醇麻醉下对电皮质谱的影响:一项前性随机试验

Chayanika Kutum¹, Priyanka Khurana², Pragati Ganjoo²

¹Department of Anaesthesiology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

Asian journal of neurosurgery

|March 5, 2026

概括

德克斯梅德托米丁与普罗波 (propofol) 麻醉相结合,在手术期间不会影响电皮质图 (ECoG) 信号. 当与异相结合时,德克斯梅德托米丁增强了ECoG信号,但保持了血液动力学稳定性和恢复.

科学领域:

神经科学是一个神经科学.
麻醉学麻醉学
手术手术手术

背景情况:

尽量减少麻醉剂对心电图 (ECoG) 信号的干扰,对于成功的手术至关重要.
据推测,德克斯梅德托米丁对ECoG的影响很小,但临床数据有限.
评估麻醉剂对ECoG的影响对于优化手术结果至关重要.

研究的目的:

评估德克斯梅德托米丁在手术期间对手术内ECoG信号的影响.
为了比较德克斯梅德托米丁与异氨酸相结合的效果,与普罗波 (propofol) 麻醉对ECoG的影响.
评估德克斯梅德托米丁在联合麻醉方案中的安全性和血液动力学效应.

主要方法:

30名患者被随机分配到德克斯梅托米丁-异花 (I组) 和德克斯梅托米丁-普罗波 (P组) 组.
在ECoG导向的手术中,德克斯梅德托米丁以玻尿酸剂的形式进行,然后在ECoG导向手术期间进行持续输液.
监测了ECoG信号,血液动力学参数,麻醉出现和意识,并在各组之间进行了比较.

主要成果:

在任何一组中,德克斯梅德米丁都没有抑制ECoG信号.
在I组 (德克斯梅丁胺-异花) 观察到ECoG得分的显著增加,但在P组 (德克斯梅丁胺-醇) 没有.
麻醉出现时间在I组比P组更长;血液动力学参数和意识发生率不受影响.

结论:

德克斯梅托米丁-普罗波麻醉适用于ECoG引导的手术,没有对ECoG,血液动力学或恢复产生不良影响.
德克斯梅德托米丁-异花麻醉并没有抑制ECoG,但增加了ECoG得分,需要进一步调查.
在ECoG引导的手术中使用德克斯梅德托米丁似乎是安全的,对ECoG信号的影响因同时使用的麻醉剂而有所不同.

关键词:

麻醉是一种麻醉.德克斯梅德米丁 (Dexmedetomidine) 是一种制剂.电皮质谱 (电皮质谱) 是一种电皮质谱.的手术的手术这是oflurane的.普罗波福尔 (Propofol) 是一种

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