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在创伤性头骨底部骨折和相关脑损伤后,下垂体轴受损

Rajendra Prasad¹, Arvind Sharma¹, Atul Kumar Khare²

¹Department of Neurosurgery, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.

Asian journal of neurosurgery

|March 5, 2026

概括

创伤性脑损伤 (TBI) 可以导致垂体激素的变化,一些激素最初会增加,然后正常化. 定期监测对于管理TBI后垂体功能障碍和确保最佳患者护理至关重要.

科学领域:

神经内分泌学神经内分泌学
创伤外科手术创伤外科

背景情况:

下垂体的位置使其容易受到头部创伤的影响.
在创伤性脑损伤 (TBI) 后的荷尔蒙产生的失败,即创伤后的脑下垂体缺陷症,往往被低估诊断.

研究的目的:

为了调查TBI后垂体激素水平的早期和晚期变化.
为了将这些荷尔蒙变化与患者的结果相关联.

主要方法:

进行了一项前性研究,涉及150名头骨底部创伤骨折的患者.
下垂体激素 (GH,TSH,ACTH,FSH,LH,益生菌) 在多次间隔测量:创伤后立即,第4天,第21天和受伤后3个月.

主要成果:

甲状腺刺激激素 (TSH) 水平最初上升,然后在21日和3个月后下降.
其他激素 (益生素,LH,FSH,ACTH,GH) 在入院时达到峰值,在第4天下降,并在21/90日正常化.

结论:

损伤当天的荷尔蒙增加可能反映了生理适应.
创伤后垂体功能障碍是显著的;一些缺陷需要急性治疗,而另一些需要观察.
定期评估和随访对于管理TBI患者至关重要.

关键词:

头部创伤是什么意思这是一种hypopituitarism.下垂体缺陷症下垂体缺陷症创伤性脑损伤是一种创伤性脑损伤

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