焦虑和胃肠道疾病之间的双向关联:使用TriNetX数据库进行的一项回顾性队列研究
Zachary Li1, Leah Morgan1, Taylor M Gong1
1Psychiatry, Drexel University College of Medicine, Wyomissing, USA.
Cureus
|March 5, 2026
概括
焦虑在两个方向上都与刺激性肠综合征 (IBS) 密切相关. 然而,焦虑和炎症性肠病 (IBD) 之间的关联较弱和不一致,表明有不同的潜在机制.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 刺激性肠综合征 (IBS) 和炎症性肠病 (IBD) 是常见的胃肠疾病,经常与焦虑和抑郁有关.
- 肠-大脑轴,肠道失调,神经免疫相互作用和共同的遗传学可能解释了这些联系.
- 这项研究量化了焦虑和IBS/IBD之间的双向关联在一个大型的真实世界数据集.
研究的目的:
- 为了比较焦虑和IBS与焦虑和IBD之间的双向关联.
- 利用一个大型的,多中心的,现实世界的数据集,进行可靠的统计分析.
- 为临床实践提供有关这些疾病的查和综合护理的信息.
主要方法:
- 使用TrinetX非识别电子健康记录 (2021-2024) 的回顾性队列研究.
- 包括患有焦虑症,IBS或IBD的成年人;不包括以前患有胃肠道疾病或相关药物使用的人.
- 倾向性得分与平衡的队列相匹配;在5年内,在焦虑后评估IBS/IBD事件和在IBS/IBD后评估事件焦虑.
主要成果:
- 焦虑显著增加了患IBS (RR 2.74) 和IBD (RR 1.56) 的风险.
- IBS显著增加了发展焦虑症的风险 (RR 2.21).
- 在IBD和随后的焦虑发展之间没有发现显著的关联 (RR 0.99).
结论:
- 在焦虑和IBS之间观察到强烈的双向关系.
- 焦虑和IBD之间的联系较弱和不一致.
- 研究结果强调了肠-大脑轴的作用,并建议综合护理方法来管理这些相互关联的条件.
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