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在接受一线化疗免疫治疗的NSCLC患者中,对六个临床预后得分的评估

Jiaqi Sun^1,2, Dan Li¹, Jiayin Liu¹

¹Department of Medical Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Frontiers in immunology

|March 5, 2026

概括

评估了6个预后得分,以预测接受一线化疗免疫疗法 (CIT) 的非小细胞肺癌 (NSCLC) 患者的预后结果. RMH,MDACC和MDACC+NLR得分显示出预后效用,最佳选择取决于临床背景.

科学领域:

在瘤学瘤学.
临床研究临床研究
生物统计学生物统计学

背景情况:

非小细胞肺癌 (NSCLC) 是癌症相关死亡的主要原因.
第一线化疗免疫疗法 (CIT) 改善了NSCLC患者的治疗结果.
准确的预后得分对于定制治疗策略至关重要.

研究的目的:

评估六个已确定的预后分数的预测有效性,以评估在接受一线CIT的NSCLC患者的结局.
为了比较RMH,MDACC,MDACC+NLR,MDA-ICI,LIPI和GRIm评分系统的性能.

主要方法:

分析了一组298名接受一线CIT的NSCLC患者.
卡普兰-梅尔曲线,考克斯回归,C指数和时间依赖的AUC用于生存分析和性能比较.
使用假发现率 (FDR) 校正的日志级别测试评估了风险组间的显著性.

主要成果:

RMH和MDACC的整体存活期 (OS) 和无进展存活期 (PFS) 的C指数较高.
MDA-ICI和MDACC+NLR显示出强的1年OS和PFS预测性表现.
在FDR校正后,MDACC与OS有显著的关联;MDACC+NLR对PFS的边际意义是显著的.

结论:

RMH,MDACC和MDACC+NLR评分系统在接受一线CIT治疗的NSCLC患者中具有预后价值.
选择最佳预后得分取决于具体的临床情景和感兴趣的结果.

关键词:

在NSCLCLC中,我们可以看到NSCLCLC.化学免疫疗法化学免疫疗法临床预后得分临床预后得分有效性有效性有效性.一线抗瘤治疗的第一线治疗.预后预后预后

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